Measurements of total and integrated HIV DNA demonstrate sporadic blips of unintegrated HIV DNA in HIV-positive patients on HAART
نویسندگان
چکیده
Methods We developed and validated a sensitive and precise assay to measure HIV integration. Total and integrated HIV DNA were then measured in a cross-sectional series of patients on HAART and in two patients longitudinally. The ratios of total over integrated were then calculated to determine the extent of unintegrated HIV DNA present in patient samples. The errors in the ratios were calculated to determine the lowest level of excess unintegrated HIV DNA that we could confidently detect.
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2010